Meet the Minors: Exploring Minor Cannabinoids

When it comes to cannabis, most of the buzz has traditionally surrounded the major cannabinoids: THC (tetrahydrocannabinol) and CBD (cannabidiol). From recreational use to therapeutic applications, these two compounds have dominated the narrative.


Beyond THC and CBD lies a rich tapestry of compounds aptly named "minor cannabinoids." Lesser-known but with an equally impressive array of potential benefits, these molecules are finally getting their moment in the spotlight.

The Diversity of Minor Cannabinoids & Their Medical Potential

The cannabis plant is a treasure trove of chemical compounds. While THC and CBD are the most widely recognized, over 100 other cannabinoids are created within this unique plant. Each cannabinoid has its distinct molecular structure, and though many are present in minute quantities, their combined effects can be profound. This vast diversity holds the potential for a range of therapeutic benefits, from pain relief to cognitive enhancement. 


Let’s look at some of the minor cannabinoids that are beginning to capture scientific and medical interest.

Cannabigerol (CBG)

CBG is often dubbed the "parent" or "stem cell" cannabinoid, as it serves as a chemical precursor to many other cannabinoids. Research has shown that CBG might be particularly effective against inflammation and bacterial growth, potentially serving as a natural antibiotic. Its non-psychoactive nature makes it even more intriguing for potential medical applications.


Its potential anti-inflammatory properties might play a pivotal role in managing conditions like Crohn's disease and irritable bowel syndrome. 

Cannabinol (CBN)

As THC ages and is exposed to oxygen, it slowly converts to CBN. CBN is especially noted for its potential sedative effects. Some studies suggest that it may be a potent sleep aid, making it interesting to those suffering from insomnia or other sleep disorders.

Preliminary studies suggest that CBN might offer potent anti-inflammatory benefits, which could be beneficial for conditions like rheumatoid arthritis. Its potential neuroprotective properties are also being explored, which could position it as a candidate for managing neurodegenerative diseases.

Cannabichromene (CBC)

Another non-psychoactive cannabinoid, CBC, may play a role in promoting brain health. Early research hints that CBC might promote the growth of neural progenitor stem cells, essential for memory and learning. Its potential anti-inflammatory and antidepressant effects further establish it as a compound of interest in managing mental health disorders.

Moreover, its anti-inflammatory, antidepressant, and antifungal properties indicate a broad spectrum of potential therapeutic applications.

Tetrahydrocannabivarin (THCV)

THCV shares a close chemical similarity with THC but has notably different effects. Whereas THC is known to stimulate appetite ("the munchies"), THCV may act as an appetite suppressant, potentially making it useful in weight management. Additionally, there's growing interest in THCV's potential to regulate blood sugar levels, positioning it as a possible aid for diabetes patients.

Cannabidivarin (CBDV)

CBDV shares structural similarities with CBD and is also non-psychoactive. Preliminary research has shown promise for CBDV in treating seizures, especially in specific forms of epilepsy resistant to other treatments. Beyond epilepsy, CBDV's anti-inflammatory and anti-nausea properties are subjects of an ongoing investigation, broadening its potential therapeutic scope.

Minor Cannabinoids in Action

Beyond their individual properties, their interaction with other compounds within the cannabis plant, thanks to the entourage effect, offers myriad health benefits. Let's dive deeper into how these minor cannabinoids are making significant inroads together, and what makes that happen.

The Entourage Effect

A foundational concept in cannabis research is the entourage effect. It posits that the cannabis plant's full therapeutic potential isn't just a result of its compounds but arises from the synergy between them. Instead of acting in isolation, these compounds – including both major and minor cannabinoids as well as terpenes – work in tandem, amplifying and modifying each other’s effects. This means that a whole-plant extract might produce effects that are more substantial and multifaceted than any single compound on its own.

When looking at the minor cannabinoids, many team up to offer bigger and better benefits than any would do solo.

  • Pain Management: CBG and CBC team up to battle inflammation, which often causes pain in conditions like arthritis. By calming down inflammation, they indirectly ease the associated pain, offering a natural alternative to traditional methods.

  • Neurological Disorders: CBG and THCV are the dynamic duo here. They might shield our brain cells from damage caused by oxidative stress and inflammation. Plus, they can have a chat with different neurotransmitter systems, potentially slowing down the progression of conditions like epilepsy, Parkinson's, and multiple sclerosis.

  • Mood and Anxiety: CBC steps up to potentially lift our mood by boosting natural mood regulators. Meanwhile, CBN and CBG work together to help reduce anxiety without the typical "high" effect, giving us a more balanced approach to emotional well-being.

  • Sleep Disorders: CBN takes the spotlight as a potential sleep savior. It might help improve sleep quality without leaving us groggy or dependent, offering a fresh way to combat insomnia and other sleep troubles.

  • Skin Conditions: CBG and CBC come to the rescue for our skin. They team up against inflammation that causes skin issues like acne or psoriasis. Plus, they also fight off harmful bacteria and fungi that mess with our skin's health.

In a nutshell, these cannabinoid pairs are like tag teams tackling different health challenges. Whether it's pain, brain health, mood, sleep, or skin problems, these duos are bringing some exciting alternatives to the table.

Beyond Cannabinoids: Terpenes and Flavonoids

The intricate beauty of the cannabis plant doesn't end with cannabinoids. Integral to the plant's uniqueness are compounds like terpenes and flavonoids, which play significant roles in both the aroma and potential therapeutic benefits of cannabis.

Terpenes are aromatic compounds responsible for the distinct scents of many plants, including cannabis. But beyond imparting aroma, they may also influence the overall effects of cannabis, potentially modulating how cannabinoids interact with our body and enhancing their therapeutic effects.

Find out more about dominant terpenes here: 

Flavonoids are a group of polyphenolic compounds found in various plants, including cannabis. Their potential antioxidant, anti-inflammatory, and neuroprotective properties make them subjects of interest in scientific circles. In cannabis, specific flavonoids called cannaflavins have been identified, which may have potent anti-inflammatory effects, exceeding those of conventional treatments in some studies.

All together, minor and major cannabinoids, terpenes, and flavonoids come together to create a holistic, full-spectrum experience. Discover the full spectrum with COTC flower and concentrates by finding a retailer near you. 

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